Author Topic: Folic Acid  (Read 1441 times)

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Offline csschick

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Folic Acid
« on: 11 January 2015, 01:12:30 PM »
Hi all,

We all know that it's recommended to take the high dose 5mg folic acid during pregnancy.

Obviously, it's to help make a healthy baby, but I'm concerned about taking such a high dose of a synthetic supplement.

I've searched the internet and Google Scholar to try and find the research that proves such a large dose is necessary but to no avail.

Can anyone help me with this?

Offline sedge

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Re: Folic Acid
« Reply #1 on: 11 January 2015, 02:34:26 PM »
I don't know, it's never been of personal interest to me, so I've never had the desire or need to know - except for interest.

However, were it of personal interest, then I would first ask the person who told me I needed it - ie the doctor who has prescribed it.

Or - start with the research that says ANY folic acid supplement is essential to all pregnant ladies, perhaps?
Jenny

T1 DX 1972, pumping Novorapid 24/05/11

HbA1c - 7/07 8.7, 1/08 7.8, 9/08 8.4, 3/09 7.3, 7/09 7.2, 12/09 7.3, 11/10 8.1, 2/11 8.6, 9/11 6.5 2/12 6.4  5/12 50/6.7  11/12 52/6.9  01/13 46/6.4  06/16 46/6.4  12/16 45/6.4

Offline himtoo

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Re: Folic Acid
« Reply #2 on: 11 January 2015, 02:54:48 PM »
hi css chick
perhaps your dsn might be able to assist on this or even the consultant


any avenue can be of use --
T1 Dia Aug 1972 -pumping omnipod since 29/09/15  Losartan 100mg , simvastatin 40mg,Furosemide 40mg, Omeprazole 80mg , Doxazosin 8mg
Hba1c - 06/2013 6.1 02/2014 43(6.1) 07/14 42(6.0) 08/14 40( 5.8 ) 12/14 39 (5.7) 08/15 41 ( 5.9) 10/15 44 ( 6.2 ) 03/16 49 (6.6)
cholesterol --nov 2011 4.3 june 2012 4.4 June 2013 4.1 Feb 2014 4.1 dec 14 4.5 oct 15 4.4
Dafne grad. necrobiosis lipoidica on legs
laser treatment on both eyes 2002 and 2012, injections left eye 3 , wearing Noctura mask since oct 2014

Offline BATcher

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Re: Folic Acid
« Reply #3 on: 11 January 2015, 04:25:30 PM »
Have a read through NHS Choices' Vitamins and nutrition in pregnancy, where it talks about the standard daily 400mcg tablet of Folic Acid, and the reasons for taking a higher dose:

Higher dose folic acid

Some women have an increased risk of having a pregnancy affected by a neural tube defect, and are advised to take a higher dose of 5 milligrams (5mg) of folic acid each day until they are 12 weeks pregnant. Women have an increased risk if they:
  •     or their partner have a neural tube defect
  •     have had a previous pregnancy affected by a neural tube defect
  •     or their partner have a family history of neural tube defects
  •     have diabetes 
Type 2, diagnosed June 1993, on insulin since May 2005; last HbA1c (Jan 2015): 38 mmol/mol = ~5.6%;
early morning: Levemir, 50 u;
at each main meal: NovoRapid, ~12-25 u, with Metformin, 2 x 500 mg;
just before bedtime: Levemir, 50 u; also aspirin, and very reluctantly atorvastatin 10 mg.

Offline Liam

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Re: Folic Acid
« Reply #4 on: 11 January 2015, 05:25:40 PM »
I know if I question my Endos advice he'll sent me links to the research that backs up his advice. Might be worth asking the person like Sedge says. Most of the mothers we're had posting have used it and had healthy babies. I don't know enough about it to really advise you.

I'm all for eating to get vitamins when I can (I've changed my diet because of this a lot because of this forum) but I still take a high dose of a 'synthetic supplement' (vit D) because the best natural source is sun light which the UK lacks and has risks of skin cancer if over done. Just an example of when a pill is useful.
DX Type I 1994.    Novorapid Animas Vibe pump
HbA1c 3/10 10.2%, 7/10 8.1%, 12/10 7.5%.
2/11 7.8%, 8/11 8.6% 9/11 8.3%.
3/12 62 (7.8%). 10/12 67 (8.3%)
4/13 63 (7.9%) 6/13 59 (7.5%)
1/14 71 (8.6%) 7/14 59 (7.5%) 11/14 (6.7%)
3/15 56 (7.3%) 12/15 49 (6.6%)
Ramipril: 10mg Quetiapine: 550mg Metformin: 2000mg

Offline BATcher

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Re: Folic Acid
« Reply #5 on: 11 January 2015, 06:56:49 PM »
I see I haven't really "answered the question" about research showing that 5mg of folic acid is advisable for to-be-pregnant diabetic females.

Provided you also search under "vitamin B9" and "folate" as well as "folic acid", you may get some useful results, such as when Googling for "high dose folic acid pregnancy research"...
Type 2, diagnosed June 1993, on insulin since May 2005; last HbA1c (Jan 2015): 38 mmol/mol = ~5.6%;
early morning: Levemir, 50 u;
at each main meal: NovoRapid, ~12-25 u, with Metformin, 2 x 500 mg;
just before bedtime: Levemir, 50 u; also aspirin, and very reluctantly atorvastatin 10 mg.

Offline Venomous

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Re: Folic Acid
« Reply #6 on: 12 January 2015, 11:44:44 AM »
Personally I would take the higher dose folic acid and also take vitamin D pills during (and before) pregnancy. If you don't want to take a supplement then research the foods high in those and eat plenty of them... I think for instance broccoli and spinach, lots of greens, and get lots of sunshine?
T2 and PCOS. Just had large serous adenofibroma removed with ovary and fallopian tube. Bp is now normal!

Novorapid, levemir, trulicity, metformin.

Online Pattidevans

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Re: Folic Acid
« Reply #7 on: 12 January 2015, 12:55:01 PM »
Quote
and get lots of sunshine?
Hmmm... sadly not much chance of that at this time of year in this country is there?
Patti


Type 1.  Mis-diagnosed T2 May 2003, finally had CPeptide test 15/7/11 and proper diagnosis 1/9/11.  Now pumping Apidra with Roche Spirit Combo pump. Hba1c 6.1 April 2016.


© 2015 Patti Evans

Offline Venomous

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Re: Folic Acid
« Reply #8 on: 12 January 2015, 05:30:42 PM »
Quote
and get lots of sunshine?
Hmmm... sadly not much chance of that at this time of year in this country is there?

Too true unfortunately! I think I remember reading all an individual needs though is about 15 minutes of daylight rather than direct sun to top up Vit D, but that's just from memory, I could easily be totally wrong.
T2 and PCOS. Just had large serous adenofibroma removed with ovary and fallopian tube. Bp is now normal!

Novorapid, levemir, trulicity, metformin.

Offline sedge

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Re: Folic Acid
« Reply #9 on: 12 January 2015, 09:16:14 PM »
Well that's all you need, unless you are actually deficient, in which case, even baking naked in the Meditterranean sunshine for 5 or 6 hours a day, for about a month at a time several times a year - isn't enough !

My GP thought he'd gone potty when he saw my results - knowing my lifestyle !
Jenny

T1 DX 1972, pumping Novorapid 24/05/11

HbA1c - 7/07 8.7, 1/08 7.8, 9/08 8.4, 3/09 7.3, 7/09 7.2, 12/09 7.3, 11/10 8.1, 2/11 8.6, 9/11 6.5 2/12 6.4  5/12 50/6.7  11/12 52/6.9  01/13 46/6.4  06/16 46/6.4  12/16 45/6.4

Offline Dollyrocker

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Re: Folic Acid
« Reply #10 on: 12 January 2015, 09:23:47 PM »
If you have reservations about taking it then don't take it, personally I would consider the potential risk to my child if I didn't take it as being greater than an assumed risk that I can't find any research or evidence to back up

No brainer surely?


7/2014 7.2 (55) / 4/2015 7.3 (56) 1/2016 7.0 (53)
pumping with a shitty Accu Chek Insight

Offline sedge

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Re: Folic Acid
« Reply #11 on: 12 January 2015, 11:03:17 PM »
Perhaps it's actually worth saying here, horrendous though it may be, that it was WELL after the War that diabetics even achived live births - usually babies were either miscarried or stillborn.

All diabetes treatment is NEW.  But live births to diabetic mums, is even newer.

We have certainly had ladies who sadly had miscarriages on the forum - but I have to say, the successful pregnancies of perfect babies FAR outnumber them.  But of course I have no idea about whether the higher dose folic did any of that as all of them presumably would have taken it.  Claire and Clare - who actually started the whole Preg section of the forum! were both on it routinely, so I've never seen posts from anyone that wasn't.

We put manufactured substances into our body every day of our lives just to stay alive in the first place - even porcine and bovine insulin always had to be processed with chemicals for humans to use it - so I just don't understand !!!
Jenny

T1 DX 1972, pumping Novorapid 24/05/11

HbA1c - 7/07 8.7, 1/08 7.8, 9/08 8.4, 3/09 7.3, 7/09 7.2, 12/09 7.3, 11/10 8.1, 2/11 8.6, 9/11 6.5 2/12 6.4  5/12 50/6.7  11/12 52/6.9  01/13 46/6.4  06/16 46/6.4  12/16 45/6.4

Offline feejee

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Re: Folic Acid
« Reply #12 on: 13 January 2015, 09:10:20 AM »
If you were really against taking the higher level dose then i would at least have a blood test done to ensure your folate levels are acceptable and not low in the first place.   

I took the higher level folic acid, and Theo has come out fine if that's of any confidence boost - and i was taking the higher level for well over a year/2 years before i got pregnant as it took rather a long time to conceive. 
Type 2. Diagnosed Feb 2012.  On metformin 2 * 1000mg. Invokana (Canagliflozin) 100mg
hbA1c on diagnosis: 128 mmol/mol or 13.8%
6/12: 60 mmol/mol or 7.8%, 
10/12: 6.6%, 03/12: 6.5% Cholesterol: 4.16 (HDL:0.88, LDL: 2.6, 3G's: 1.56)
10/14: 5.6%
02/16: 7.5%
02/16
6/13: 6.6%
4/14@:5.7%

Offline M

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Re: Folic Acid
« Reply #13 on: 13 January 2015, 09:47:13 PM »
Hi,


I wouldn't worry about taking the higher dose as anything your body doesn't need just gets passed out in your urine so no chance of over dosing.
T1 Diabetic for 24 years. On accu check combo pump. Last HbA1c 39/5.7