Author Topic: Empagliflozin  (Read 682 times)

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Offline Moby

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Empagliflozin
« on: 13 January 2017, 11:38:02 AM »

Nursery nightshade is on my case. It's not a surprise tbh. :nurse:
cut my insulin, and have lost 3st. Feel fitter but obviously running higher than normal.
its an educated decision because i can't lose the weight any other way.
anyway she's suggested Empagliflozin.
I've read the links for side effects etc, just wanted to ask if anyone is/has been on it, and, how did it go?
thanks .

bw
Moby

T2 since 2002.
metformin 2000mg. humalin I and humalog
Xpert graduate & Xpert Insulin Graduate. (for what it's worth)


©Martin Cronshaw 2015

Offline everydayupsanddowns

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Re: Empagliflozin
« Reply #1 on: 13 January 2017, 12:53:47 PM »
Sorry Mobes, not one I've heard of.
Mike

Type 1 since: 1991 Last HBA1c: 45 (6.3%)  Total Chol 5.0 (1.9HDL / 2.8LDL / Trigs 0.7)
Pumping NovoRapid in a MiniMed 640G
Blogging at: www.everydayupsanddowns.co.uk

Offline Pattidevans

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Re: Empagliflozin
« Reply #2 on: 13 January 2017, 01:33:36 PM »
Hi Moby

Good news on the weight loss anyway! Wish I could lose some, have gained 5lbs since I stopped taking Metformin.

There's some good information on Empagliflozin here https://www.drugs.com/cdi/empagliflozin.html

It works similarly to canagliflozin & Dapagliflozin in other words you pee the glucose out.  Several members are on one or t'other of those (inc. Libre Jenny). 
Patti


Type 1.  Mis-diagnosed T2 May 2003, finally had CPeptide test 15/7/11 and proper diagnosis 1/9/11.  Now pumping Apidra with Roche Spirit Combo pump. Hba1c 6.1 April 2016.


© 2015 Patti Evans

Offline sedge

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Re: Empagliflozin
« Reply #3 on: 13 January 2017, 03:58:33 PM »
Question - peeing out glucose - whilst yes it's helping get rid of unused glucose - my understanding is that it isn't good for the kidneys, which aren't designed to process high amounts of glucose and unless you stop forcing it through - you'll damage them.

So - how can any drug that makes them do it more than they do in the normal course of events actually be good for you?

Perhaps it's simply that the high BG will kill you quicker than your kidneys will fail?

Sorry to throw doubt (if i'm correct that is, and I quite easily could be wrong - it's not an area of personal expertise LOL) on something that could help - but were I you, I'd have to find out the answer!  And I'm perfectly certain Nursie Nightshade won't be an expert.
Jenny

T1 DX 1972, pumping Novorapid 24/05/11

HbA1c - 7/07 8.7, 1/08 7.8, 9/08 8.4, 3/09 7.3, 7/09 7.2, 12/09 7.3, 11/10 8.1, 2/11 8.6, 9/11 6.5 2/12 6.4  5/12 50/6.7  11/12 52/6.9  01/13 46/6.4  06/16 46/6.4  12/16 45/6.4

Offline Pattidevans

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Re: Empagliflozin
« Reply #4 on: 13 January 2017, 05:03:02 PM »
It also seems to have some nasty side effects such as thrush and urinary infections.
Patti


Type 1.  Mis-diagnosed T2 May 2003, finally had CPeptide test 15/7/11 and proper diagnosis 1/9/11.  Now pumping Apidra with Roche Spirit Combo pump. Hba1c 6.1 April 2016.


© 2015 Patti Evans

Offline sedge

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Re: Empagliflozin
« Reply #5 on: 13 January 2017, 10:36:38 PM »
Oh that's odd - two of the EXACT things that high BGs cause .....
Jenny

T1 DX 1972, pumping Novorapid 24/05/11

HbA1c - 7/07 8.7, 1/08 7.8, 9/08 8.4, 3/09 7.3, 7/09 7.2, 12/09 7.3, 11/10 8.1, 2/11 8.6, 9/11 6.5 2/12 6.4  5/12 50/6.7  11/12 52/6.9  01/13 46/6.4  06/16 46/6.4  12/16 45/6.4

Offline Lucy

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Re: Empagliflozin
« Reply #6 on: 14 January 2017, 06:45:15 PM »
Oh that's odd - two of the EXACT things that high BGs cause .....

Thats because it works the same way - high bgs make you pee out sugar. This medicine just makes you pee out sugar to stop you getting high enough that your body makes you pee it out. All the sugar passing through there has the same effect regardless of the reason the peeing sugar.
Type: Lucy. A1C 44 / 6.0% Jan17.
Lantus, Victoza and Apidra. Metformin XR, Bisoprolol (for SVT). Dexcom G4 with xdrip and nightscout.

Offline sedge

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Re: Empagliflozin
« Reply #7 on: 14 January 2017, 10:34:59 PM »
That's what worries me, Lucy.
Jenny

T1 DX 1972, pumping Novorapid 24/05/11

HbA1c - 7/07 8.7, 1/08 7.8, 9/08 8.4, 3/09 7.3, 7/09 7.2, 12/09 7.3, 11/10 8.1, 2/11 8.6, 9/11 6.5 2/12 6.4  5/12 50/6.7  11/12 52/6.9  01/13 46/6.4  06/16 46/6.4  12/16 45/6.4

Offline GrammaBear

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Re: Empagliflozin
« Reply #8 on: 15 January 2017, 12:18:12 AM »
I found this link, https://en.wikipedia.org/wiki/Empagliflozin, for whatever help it might be.
Type 1
Tandem Tslim pump Oct 2015
Dexcom G4 CGM Sep 2007
A1C 6.5%~ Sep 2017

Offline Pattidevans

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Re: Empagliflozin
« Reply #9 on: 15 January 2017, 09:13:13 AM »
There is a lot more info, inc the side effects here https://www.drugs.com/cdi/empagliflozin.html

Patti


Type 1.  Mis-diagnosed T2 May 2003, finally had CPeptide test 15/7/11 and proper diagnosis 1/9/11.  Now pumping Apidra with Roche Spirit Combo pump. Hba1c 6.1 April 2016.


© 2015 Patti Evans

Offline Venomous

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Re: Empagliflozin
« Reply #10 on: 15 January 2017, 12:52:20 PM »
I think it'd be sensible to drink a lot with it if you are going to take it.

Just about all of the T2 diabetic meds affect the body negatively in some way... its sadly a case of pick your poison.
T2 and PCOS. Just had large serous adenofibroma removed with ovary and fallopian tube. Bp is now normal!

Novorapid, levemir, trulicity, metformin.

Offline Moby

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Re: Empagliflozin
« Reply #11 on: 20 January 2017, 12:03:23 AM »
Apparently  the kidneys WANT to re absorb as much  glucose as possible,  despite the fact that us sickies are trying to pee it out.
So if the glucose in your urine is high, your body responsible absorbs it through the kidneys. Marvellous, news !
Empagiflozin works by stopping glucose re absorption and can act as a weight loss aid.

The locum gp I saw the other day is a good un. Speaks his mind and gives it straight.
Agrees with the LCHF diet, can't understand the eatwell  plate. He also said the NHS stance on dietary advice  for t2's is crap. (His exact words)

I have pointed him to the blogs of malcolm kendrick,  professor unger,  uffe ranskoff ? And Zoe harcombe.

He has promised to do some reading!

More surfing to do before I decide. Excerise is my lacking  factor, but I find it difficult to squeeze  in atm,.

Keep well!
bw
Moby

T2 since 2002.
metformin 2000mg. humalin I and humalog
Xpert graduate & Xpert Insulin Graduate. (for what it's worth)


©Martin Cronshaw 2015

Offline Pattidevans

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Re: Empagliflozin
« Reply #12 on: 20 January 2017, 04:13:07 PM »
Quote
Apparently  the kidneys WANT to re absorb as much  glucose as possible,  despite the fact that us sickies are trying to pee it out.
So if the glucose in your urine is high, your body responsible absorbs it through the kidneys. Marvellous, news !
Empagiflozin works by stopping glucose re absorption and can act as a weight loss aid.
Really?  It can help weight loss?  I am surprised.
Quote
The locum gp I saw the other day is a good un. Speaks his mind and gives it straight.
Agrees with the LCHF diet, can't understand the eatwell  plate. He also said the NHS stance on dietary advice  for t2's is crap. (His exact words)

I have pointed him to the blogs of malcolm kendrick,  professor unger,  uffe ranskoff ? And Zoe harcombe.

He has promised to do some reading!

He sounds like a keeper, pity he is a locum.  However it's very nice to know that it is filtering through to the medical profession that the eatwell plate is rubbish and the dietary advice to T2s is crap and making them worse!  Are you likely to see him again?
Patti


Type 1.  Mis-diagnosed T2 May 2003, finally had CPeptide test 15/7/11 and proper diagnosis 1/9/11.  Now pumping Apidra with Roche Spirit Combo pump. Hba1c 6.1 April 2016.


© 2015 Patti Evans

Offline Liam

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Re: Empagliflozin
« Reply #13 on: 20 January 2017, 04:15:52 PM »
Well the weightloss would be from the glucose being peed out rather than stored as fat right? Bit like DKA lasting for ages (i.e. before type I diagnosis)
DX Type I 1994.    Novorapid Animas Vibe pump
HbA1c 3/10 10.2%, 7/10 8.1%, 12/10 7.5%.
2/11 7.8%, 8/11 8.6% 9/11 8.3%.
3/12 62 (7.8%). 10/12 67 (8.3%)
4/13 63 (7.9%) 6/13 59 (7.5%)
1/14 71 (8.6%) 7/14 59 (7.5%) 11/14 (6.7%)
3/15 56 (7.3%) 12/15 49 (6.6%)
Ramipril: 10mg Quetiapine: 550mg Metformin: 2000mg

Offline Pattidevans

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Re: Empagliflozin
« Reply #14 on: 20 January 2017, 04:59:00 PM »
Well the weightloss would be from the glucose being peed out rather than stored as fat right? Bit like DKA lasting for ages (i.e. before type I diagnosis)

Along the lines of what I was thinking Liam, but if you can keep the BGs at a reasonable level you shouldn't be needing to pee it out.  With a T1 the high BGs before dx mean that the body is consuming it's own fat, hence the ketones.
Patti


Type 1.  Mis-diagnosed T2 May 2003, finally had CPeptide test 15/7/11 and proper diagnosis 1/9/11.  Now pumping Apidra with Roche Spirit Combo pump. Hba1c 6.1 April 2016.


© 2015 Patti Evans