Thing I'd want to know is - ok, great, we're seeing the lowest chol figures ever in hospitals...so...are we seeing any less heart disease and arterial disease?Here are the mortality figures fromt he study:
• The total number of deaths from cardiovascular disease in the Repatha group was 251
• The total number of deaths from cardiovascular disease in the placebo group was 240
• So, 11 more people died of cardiovascular disease in the Repatha group
The overall mortality data
• The total number of, overall, deaths in the Repatha group was 444
• The total number of, overall, deaths in the placebo group was 426
• So, there were 18 more deaths in those taking Repatha.
That's from Dr Kendrick's blog that Patti posted the link to. Dr K says those diferences are "insignificant statistically" !
And I guess they are, because the study size was so enormous - 17,000 was it? Or was that the other one and it was 27,000.
The really striking thing that he picked up on was that both this study and the other one were stopped half way through. Now this *can* happen when early results are so conclusive that it can be argued that it would be immoral to put the placebo patients at ongoing risk by denying them wonderdrug X, but the earlier study was stopped and the development of it stopped. Plus the fact that over the course of the study mortality/CVD was pretty much identical for placebo and intervention arms - so there would be no moral duty to stop the study on that basis.
I go round and round in circles about cholesterol, because there IS good evidence for improved outcomes in a significant body of research that (if it existed for CGM for example) I would be jumping up and down to get whatever it was made available. BUT... I also see other good evidence that those self same studies actually only show very modest results - if any results at all, and may (or may not) be skewed by industry-sponsorship and/or underreporting of side effects.
As with so many things, it seems to depend on whether or not you have already made up your mind one way or the other. And there is always ample evidence to support each of our confirmation biases, Drs and patients alike!